EquiDol | Natural supplement for pain relief

𝐄𝐪𝐮𝐢𝐃𝐨𝐥 è un integratore alimentare completamente naturale, a base di estratti vegetali e micronutrienti selezionati e altamente biodisponibili, formulato per supportare il 𝐛𝐞𝐧𝐞𝐬𝐬𝐞𝐫𝐞 𝐦𝐮𝐬𝐜𝐨𝐥𝐚𝐫𝐞 𝐞 𝐚𝐫𝐭𝐢𝐜𝐨𝐥𝐚𝐫𝐞 e favorire un’azione completa su dolore, rigidità e affaticamento.

𝐈𝐧𝐠𝐫𝐞𝐝𝐢𝐞𝐧𝐭𝐢: Magnesio ossido; Magnesio bisglicinato; Estratto secco di Boswellia serrata (titolato al 65%); Estratto secco di Withania somnifera (titolato al 2,5%); Creatina (200 mesh); PEA (Palmitoiletanolamide);Vitamina D3; Cellulosa
microcristallina; Magnesio stearato.

𝐂𝐚𝐩𝐬𝐮𝐥𝐚: idrossipropilmetilcellulosa (capsula vegetale).
Dose giornaliera consigliata: 2 capsule al giorno (1 prima di pranzo e 1 prima di cena).

𝐈𝐧𝐭𝐞𝐠𝐫𝐚𝐭𝐨𝐫𝐞 𝐚𝐥𝐢𝐦𝐞𝐧𝐭𝐚𝐫𝐞.
Non superare la dose giornaliera consigliata.
Gli integratori non vanno intesi come sostituti di una dieta varia ed equilibrata e di uno stile di vita sano.

Tenere fuori dalla portata dei bambini al di sotto dei 3 anni.

is recommended to take 2 capsules a day, with a glass
of water:
● 1 capsule before lunch
● 1 capsule before dinner

For more effective support for pain, stiffness and fatigue, it is recommended to combine EquiDol with a healthy lifestyle, including regular movement and gentle activity compatible with your condition. A first supplementation cycle of at least three continuous months is recommended, especially for persistent pain, to promote a stable effect and reduce the risk of relapse

Do not exceed the recommended daily dose.
Keep out of reach of children under 3 years of age. Food supplements are not intended to replace a varied and balanced diet and a healthy lifestyle. In case of pregnancy, breastfeeding or ongoing pharmacological treatments, consult your doctor before use. Store in a cool, dry place, away from light and sources of heat.

PEA (Palmitoylethanolamide) – Scientific evidence for natural support in chronic pain
Palmitoylethanolamide (PEA) is a naturally occurring lipid compound found in the body and also available via supplementation. It is known for its anti-inflammatory, analgesic and neuroprotective properties, with mechanisms that include modulation of the inflammatory response and regulation of pain signaling.

Main evidence:

● Chronic pain management: a meta-analysis of randomized controlled clinical trials showed that PEA supplementation is associated with a significant reduction in pain intensity compared with placebo or other controls, with improvements also in quality of life and functional status.
● Tolerability: PEA formulations were well tolerated without serious adverse effects in the trials reviewed.
● Fibromyalgia: in observational studies of patients with fibromyalgia, adding PEA to standard therapy showed additional benefits in reducing pain and tender points compared with pharmacological therapy alone.
● Biological mechanisms: PEA acts by modulating inflammation and neuronal sensitivity, affecting immune cells such as mast cells and microglia involved in the perception of chronic pain.

🔗Scientific reference:
https://pubmed.ncbi.nlm.nih.gov/36986081/

Boswellia serrata – Scientific evidence for natural support of inflammation and pain
Boswellia serrata is a plant traditionally used to treat chronic inflammatory conditions. A scientific review (2011) highlights that its resin contains boswellic acids, bioactive compounds known for their ability to inhibit pro-inflammatory enzymes involved in pain and inflammation processes.

In particular, acetyl-11-keto-β-boswellic acid (AKBA) is cited as one of the most potent at blocking 5-lipoxygenase (5-LOX), a key enzyme in the production of inflammatory mediators. This mechanism makes Boswellia a promising natural support for joint pain and inflammation-related issues.

🔗 Scientific reference:
https://pubmed.ncbi.nlm.nih.gov/22457547/

Withania somnifera (Ashwagandha) - Scientific evidence on analgesic activity
A clinical study on healthy volunteers tested the analgesic activity of a standardized Ashwagandha extract using an experimental pain model (Hot Air Pain Model), comparing it with placebo. The result was an increase in pain threshold.

🔗Scientific reference:
https://www.academia.edu/71694038/